Wellbutrin XL (Bupropion Hydrochloride)

• Antidepressant, specifically a norepinephrine-dopamine reuptake inhibitor (NDRI).

Indications

• Used for the treatment of major depressive disorder (MDD).
• Used for the prevention of seasonal affective disorder (SAD).

Dosage Forms

• Available in extended-release tablets of various strengths (e.g., 150 mg, 300 mg).

Administration

• Taken orally, typically once a day in the morning.
• Tablets should be swallowed whole, not crushed, divided, or chewed.

Dosage

• Varies based on individual needs and medical conditions.
• Usually starts with a lower dose, may be increased gradually.

Side Effects

• Common: Dry mouth, headache, nausea, insomnia, sweating.
• Serious: Seizures, high blood pressure, severe allergic reactions, mood changes (e.g., agitation, hallucinations).

Precautions

• Not recommended for individuals with seizure disorders or those allergic to bupropion.
• Use caution in patients with a history of bipolar disorder.
• Avoid abrupt discontinuation of the medication.

Interactions

• Can interact with MAO inhibitors, other antidepressants, certain antipsychotics, theophylline, and systemic steroids.
• Alcohol and CNS depressants may increase risk of adverse effects.

Pregnancy and Lactation

• Use only if potential benefit justifies potential risk to the fetus.
• Bupropion passes into breast milk; weigh risks and benefits.

Storage

• Store at room temperature, away from moisture and heat.
• Keep out of reach of children.